Endocannabinoid System??

Unlock the secrets of your body's healing potential as we dive into the endocannabinoid system. Have you ever wondered how your body manages pain, mood, and inflammation, or how it adapts to challenges like Alzheimer's or PTSD? This Cannabis Biology/Chemistry episode will begin to unravel these mysteries and more, showcasing the endocannabinoid system's incredible potential for therapeutic applications. Discover how receptors-CB1 and CB2 are spread throughout the brain and body, guiding crucial processes affecting everything from gut health to brain development, with help from our signaling molecules like anandamide (AEA), 2-AG, as well as Enzymes.

Join me as we explore the complexity of this system in maintaining balance and harmony in our bodies. There is promising potential in treating conditions like pain, cancer, heart disease, and degenerative brain diseases. Through ongoing research and insights about our body's own Endocannabinoid System, the time is exciting as we are paving the way for innovative health and disease management strategies.

Disclaimer: Information given here is to be used as your human right and by no means treating or diagnosing upon offering this data, for your knowledge only.
Please contact your health care provider if needing help.  Be is not a chemist or Biology expert, she has studied basic biology over the years..AI was used here only for the purpose of transcribing my audio recordings & notes, which then I edited:)

Be Cretilli is a Certified Cannabinoid Coach, BA degree in Natural Health (2008), Herbalist, Holistic Health Coach, holding many other holistic wellness certifications as well.  She has been a Grower &/or Cultivar since 1990!

Dr Mary Clifton, MD; Cannabinoid Protocol Courses-Coaches, 2020-21

CBD, Patient's Guide to Medical Cannabis; Leinow & Birnbaum

NIH; Cannabinoid, BBB, & Brain Disposition
https://pmc.ncbi.nlm.nih.gov/articles/PMC7150944/

Chapters

• 0:00 Understanding the Endocannabinoid System
• 10:33 The Importance of the Endocannabinoid System

Transcript

Speaker 1: 0:00

The endocannabinoid system restores balance wherever illness and injury occurs. It has therapeutic potential in almost all diseases, including obesity or metabolic syndrome, diabetes and diabetic complications, neurodegenerative diseases, inflammation, cardiovascular disease, liver and gastrointestinal diseases, skin diseases, diseases, pain, psychiatric disorders, cancers, chemotherapy-induced nausea and vomiting, among many other things as well. The understanding of this system is that there is two receptors CB1 and CB2, that have various sites inside the body. The CB1 receptor is found mostly in the brain and the CB2 receptor is found in peripheral areas, mostly in the immune system. There's two signaling molecules that help transport cannabinoids into these receptors. The molecules are AEA, or anandamide, and 2AG.

Speaker 1: 1:53

There's five key enzymes that are also involved in moving the medicine around the body. That's what enzymes do. They are involved in moving nutrients and you know, different substances around the body, metabolic actions, and I'm not going to go into the technical names of the enzymes, but there are five quote unquote cannabinoid enzymes. But there are five quote-unquote cannabinoid enzymes and the endocannabinoid system has several unique and remarkable actions. Right, there is the two on-demand substances or molecules, aea and 2AG, and they exist as common molecular parts until the CB1 and CB2 receptors are filled up or increase and into the central nervous system or in the other organ systems in the body. And once this occurs, then the transmitters are constructed on demand to work in seconds and disappear into spare parts again they are gone almost as fast as they appear. Despair parts again they are gone almost as fast as they appear. This system, the endocannabinoid system, is literally storing up its main components, creating them on demand. It's responsible for rebalancing the most essential systems in the body to control pain, mood, inflammation, energy, wellness and illness. The actions it plays go from maintaining balance or homeostasis between physical buildup and breakdown to fighting disease or injuries, breakdown to fighting disease or injuries.

Speaker 1: 4:09

The complex interplay of the endocannabinoid system with other body and brain systems involves interactions of the endocannabinoids with endorphins, hormones, cytokines and growth factors, pleasure molecules, immune cells, connective tissue systems, bone metabolism, nerve and glial cell inflammation, cell regeneration and programmed cell death. Needless to say, this is a system of immeasurable importance and we are in the vigorous research stages of understanding the complexity that's at play here. So when the CB1 receptors are activated in the brain, the result is an experience of pain relief, anxiety relief, mood stabilization, well-being and pleasure. And when the brain-based CB2 receptors are activated, local anti-inflammatory responses occur as well. Local anti-inflammatory responses occur as well. So that's like anti-inflammatory times two, with both the CB1 and CB2 receptors in the brain being experienced, and this does far more than just relieve pain, because it also is becoming evident that chronic brain inflammation is involved in Alzheimer's, post-traumatic stress disorder, ptsd, ms, multiple sclerosis, parkinson's disease, depression, autoimmune disorders and cancers, autoimmune disorders and cancers. Cb1 receptors also affect the release of other neurotransmitters like neuroepinephrine, serotonin, dopamine, orexin, histamine, gaba and other endorphins. And since the CB1 receptors are frequently located all over our nervous system, they affect many of our automatic functions in the brain and the body via our automatic nervous system, resulting in fine-tuning everything from breathing and heart rate to connective tissue health and metabolic rate. Even seizures. Cb1 and CB2 have a profound effect on the gut health as well. A 2016 study concluded that virtually all major GI functions are controlled by the endocannabinoid system. For example, cb1 receptor activation promotes increased blood lipid levels and liver fibrosis, but then the CB2 receptors, when activated, decrease blood lipid levels, fibrosis. Activated decrease blood lipid levels, fibrosis and liver inflammation an example of how these receptors frequently have opposite effects in the body. Activation of both CB1 and CB2 plays a role in how the brain develops in the growing embryo, which affects the development of nerve cells that produce GABA and slows down excess activity of GABA in the brain. Furthermore, these receptors are involved in embryonic brain development, health protection and regulation of intellectual function of nerve cells. The endocannabinoid system is also involved in new nerve cell formation in the adult brain. This is a great discovery, meaning that it's highly involved in regulation of adult neuroplasticity throughout life.

Speaker 1: 8:21

Going back to the molecules of AEA and 2-AG, aea is specific to CB1 receptors and 2-AG to CB2 receptors, but they each activate both receptor types as well. The two signaling molecules regulate each other's levels in the brain and in the brain. They not only oppose inflammation, but also are involved in trimming away old synapses to make way for new creation of new ones. Another example is AEA blocking CB1 receptors inside of nerve cells, clears beta amyloid and the inflammation it creates to prevent nerve cell death, one of the major processes in Alzheimer's disease. Besides working with CB1 and CB2 receptors, these molecules also influence processes in the body without working on these cannabinoid receptors. They attach to both nerve cells and glial cells in the brain and work deeply in the inflammatory system of the body on multiple aspects of inflammation. Aea and 2-AG also help promote sleep and block anxiety system has the enzymes that work on the raw material in the body, making AEA and 2AG. No-transcript Drugs or pharmaceutical drugs, on the other hand, completely block these enzymes and have profound negative effects on the body, resulting in symptoms ranging from brain damage to death.

Speaker 1: 10:33

Complexity and the richness of our endocannabinoid system to sustain life being fed by cannabinoids. Unlike the endocannabinoid system, drugs do not work in a pinpoint fashion. They're likely to produce multiple off-target effects. Our endocannabinoid system is extremely important system to our survival. It maintains and restores balance in the body in multiple ways. If injury or a disease occurs, the system shifts from one that regulates well-being, pleasure and energy to one that restores balance and normal functioning processes, also simultaneously pinpointing actions and is active throughout the body, affecting conditions from multiple forms of cancer, heart disease, osteoporosis, degenerative brain diseases, inflammation, pain and our mood. I just want to state that brain regions throughout that are abundant in cannabinoid receptors include our basal ganglia plays a role in movement control. Our cerebellum playing a role in body movement coordination. Hippocampus, playing a role in our learning and memory and stress and stress. Cerebral cortex, which is for our higher cognitive function. Intrabulbular anterior, which links between our cerebral hemispheres and our nucleus accumbens, which is for reward pathways and